Immunoglobulin E sialylation regulates allergic responses

Markus M Xie; Carolyn R Bertozzi; Taia T Wang

doi:10.1111/imcb.12368

Immunoglobulin E sialylation regulates allergic responses

Immunol Cell Biol. 2020 Sep;98(8):617-619. doi: 10.1111/imcb.12368. Epub 2020 Jul 7.

Authors

Markus M Xie¹, Carolyn R Bertozzi^{2

3

4

5}, Taia T Wang^{1

6

7}

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.
² Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
³ Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
⁴ Department of Chemistry, Stanford University, Stanford, CA, USA.
⁵ Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
⁶ Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
⁷ Chan Zuckerberg Biohub, San Francisco, CA, USA.

PMID: 32632971
DOI: 10.1111/imcb.12368

Abstract

Shade et al. demonstrate that people with peanut allergies produce IgE antibodies that are enriched for sialic acid-containing glycoforms. The sialylated IgE triggered significantly more degranulation by basophils and mast cells, suggesting intrinsic functional differences between IgEs from allergic and nonallergic subjects.

Publication types

Comment

MeSH terms

Basophils
Humans
Immunoglobulin E*
Mast Cells
Peanut Hypersensitivity*
Virulence

Substances

Immunoglobulin E