Noninvasive acoustic manipulation of objects in a living body

Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):16848-16855. doi: 10.1073/pnas.2001779117. Epub 2020 Jul 6.

Abstract

In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogrammed paths, in a water bath, and in the urinary bladders of live pigs. Deviation from the intended path was on average <10%. No injury was found on the bladder wall or intervening tissue.

Keywords: acoustic radiation force; acoustic tweezers; kidney stones.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Kidney Calculi / therapy*
  • Swine
  • Transducers
  • Ultrasonic Therapy / instrumentation
  • Ultrasonic Therapy / methods*
  • Ultrasonic Waves*