1 Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK, 73104-5005, USA. jonathan-wren@omrf.org.
2 Biochemistry and Molecular Biology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jonathan-wren@omrf.org.
3 Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA. jonathan-wren@omrf.org.
4 Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA. jonathan-wren@omrf.org.
5 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
6 Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
7 Department of Computer Science, University of Alabama at Birmingham, Birmingham, AL, 35294-1241, USA.
8 Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, 48309-4482, USA.