Breast cancer animal models and applications

Li Zeng; Wei Li; Ce-Shi Chen

doi:10.24272/j.issn.2095-8137.2020.095

Breast cancer animal models and applications

Zool Res. 2020 Sep 18;41(5):477-494. doi: 10.24272/j.issn.2095-8137.2020.095.

Authors

Li Zeng^{1

2}, Wei Li^{1

2}, Ce-Shi Chen^{1

3}

Affiliations

¹ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
² Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
³ KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. E-mail: chenc@mail.kiz.ac.cn.

Abstract

Breast cancer is the most common malignancy in women. Basic and translational breast cancer research relies heavily on experimental animal models. Ideally, such models for breast cancer should have commonality with human breast cancer in terms of tumor etiology, biological behavior, pathology, and response to therapeutics. This review introduces current progress in different breast cancer experimental animal models and analyzes their characteristics, advantages, disadvantages, and potential applications. Finally, we propose future research directions for breast cancer animal models.

Keywords: Animal models; Breast cancer; Drug development; Metastasis.

Publication types

Review

MeSH terms

Animals
Breast Neoplasms / pathology*
Breast Neoplasms / therapy*
Disease Models, Animal*
Female
Humans
Mammary Neoplasms, Animal / pathology*
Mammary Neoplasms, Animal / therapy*

Grants and funding

This study was supported in part by grants from the National Key R&D Program of China (2018YFC2000400), National Natural Science Foundation of China (81830087, U1602221, 31771516), and Project of Innovative Research Team of Yunnan Province (2019HC005)