Eutyscoparols A-G, polyketide derivatives from endophytic fungus Eutypella scoparia SCBG-8

Abstract

The chemical investigation on Eutypella scoparia SCBG-8, an endophytic fungus isolated from the leaves of Leptospermum brachyandrum, has resulted in the isolation of six new phenolic compounds eutyscoparols A-F (1-6) and one new natural product eutyscoparol G (7). The structures and absolute configurations of compounds 1-7 were determined by extensive chemical and spectroscopic analyses such as single crystal X-ray diffractions. Moreover, all compounds were evaluated for their antibacterial and cytotoxic activities in vitro.

Keywords: Antibacterial activity; Cytotoxic activity; Eutypella scoparia; Leptospermum brachyandrum.