EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease

Vitalii V Kozak; Menorca Chaturvedi; Ute Gschwandtner; Florian Hatz; Antonia Meyer; Volker Roth; Peter Fuhr

doi:10.3389/fnagi.2020.00171

EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease

Front Aging Neurosci. 2020 Jun 18:12:171. doi: 10.3389/fnagi.2020.00171. eCollection 2020.

Authors

Vitalii V Kozak¹, Menorca Chaturvedi^{1

2}, Ute Gschwandtner¹, Florian Hatz¹, Antonia Meyer¹, Volker Roth², Peter Fuhr¹

Affiliations

¹ Neurology and Neurophysiology, University Hospital of Basel, Basel, Switzerland.
² Mathematics and Computer Science, University of Basel, Basel, Switzerland.

Abstract

Objective: We aimed to determine whether the combination of two parameters: (a) score of axial impairment and limb rigidity (SAILR) with (b) EEG global relative median power in the frequency range theta 4-8 Hz (GRMPT) predicted cognitive outcome in patients with Parkinson's disease (PD) better than each of these measures alone. Methods: 47 non-demented patients with PD were examined and re-examined after 3 years. At both time-points, the patients underwent a comprehensive neuropsychological and neurological assessment and EEG in eyes-closed resting-state condition. The results of cognitive tests were normalized and individually summarized to obtain a "global cognitive score" (GCS). Change of GCS was used to represent cognitive changes over time. GRMPT and SAILR was used for further analysis. Linear regression models were calculated. Results: GRMPT and SAILR independently predicted cognitive change. Combination of GRMPT and SAILR improved the significance of the regression model as compared to using each of these measures alone. GRMPT and SAILR only slightly correlate between each other. Conclusion: The combination of axial signs and rigidity with quantitative EEG improves early identification of patients with PD prone to severe cognitive decline. GRMPT and SAILR seem to reflect different disease mechanisms. Significance Combination of EEG and axial motor impairment assessment may be a valuable marker in the cognitive prognosis of PD.

Keywords: EEG; Parkinson's disease; axial motor impairment; cognitive impairment; prediction.