Permeation of skin with (C60) fullerene dispersions

Madalena Martins; Nuno G Azoia; Manuel Melle-Franco; Artur Ribeiro; Artur Cavaco-Paulo

doi:10.1002/elsc.201600244

Permeation of skin with (C₆₀) fullerene dispersions

Eng Life Sci. 2017 Feb 15;17(7):732-738. doi: 10.1002/elsc.201600244. eCollection 2017 Jul.

Authors

Madalena Martins¹, Nuno G Azoia¹, Manuel Melle-Franco², Artur Ribeiro¹, Artur Cavaco-Paulo¹

Affiliations

¹ Centre of Biological Engineering (CEB) University of Minho Campus of Gualtar Braga Portugal.
² CICECO-Aveiro Institute of Materials University of Aveiro Campus Universitário de Santiago Aveiro Portugal.

Abstract

Dispersions in transcutol/isopropyl myristate make C₆₀ fullerene molecules suitable for transdermal delivery. We found that C₆₀ can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents show a high potential for delivery of C₆₀ for biopharmaceutical and cosmetics applications.

Keywords: Cosmetics; Delivery; Dispersion; Fullerene C60; Transdermal.