First report of meningococcal ciprofloxacin resistance in Greece due to invasive isolates of the sequence type ST-3129

Eur J Clin Microbiol Infect Dis. 2020 Dec;39(12):2467-2470. doi: 10.1007/s10096-020-03965-x. Epub 2020 Jul 3.

Abstract

A local outbreak caused by Neisseria meningitidis occurred in the migration camp in the Greek island of Lesbos during January-February 2020 (4 of 5 cases). In total, 5 samples positive for N. meningitidis were further investigated for sero-/genogroup, PorA, and WGS analysis. MenB was found among 3 cases, while in two cases, MenY was identified. WGS analysis and antibiotic susceptibility testing on the 2 culture positive MenB samples showed the new ST-3129, ciprofloxacin-resistant clone was circulating among the immigrants in the aforementioned camp. This is the first report of ciprofloxacin resistance in Greece.

Keywords: Ciprofloxacin resistance; Multi locus sequence typing; Neisseria meningitidis; WGS.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child, Preschool
  • Ciprofloxacin / adverse effects*
  • Ciprofloxacin / therapeutic use
  • Drug Resistance, Bacterial / genetics*
  • Female
  • Greece
  • Humans
  • Infant
  • Male
  • Meningococcal Infections / blood
  • Meningococcal Infections / diagnosis*
  • Meningococcal Infections / drug therapy
  • Meningococcal Infections / microbiology*
  • Multilocus Sequence Typing
  • Neisseria meningitidis / drug effects
  • Neisseria meningitidis / genetics
  • Neisseria meningitidis / isolation & purification*
  • Serogroup
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin