Recent developments in regenerative ophthalmology

Sci China Life Sci. 2020 Oct;63(10):1450-1490. doi: 10.1007/s11427-019-1684-x. Epub 2020 Jul 2.

Abstract

Regenerative medicine (RM) is one of the most promising disciplines for advancements in modern medicine, and regenerative ophthalmology (RO) is one of the most active fields of regenerative medicine. This review aims to provide an overview of regenerative ophthalmology, including the range of tools and materials being used, and to describe its application in ophthalmologic subspecialties, with the exception of surgical implantation of artificial tissues or organs (e.g., contact lens, artificial cornea, intraocular lens, artificial retina, and bionic eyes) due to space limitations. In addition, current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted.

Keywords: biomaterials; cell/tissue therapy; regenerative medicine; regenerative ophthalmology; stem cells; tissue engineering.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / therapeutic use
  • Biological Products / therapeutic use
  • Cell- and Tissue-Based Therapy
  • Gene Editing
  • Humans
  • Ophthalmology / instrumentation
  • Ophthalmology / trends*
  • Regenerative Medicine / instrumentation
  • Regenerative Medicine / trends*
  • Smart Materials / chemistry
  • Smart Materials / therapeutic use
  • Stem Cells / cytology
  • Tissue Engineering

Substances

  • Biocompatible Materials
  • Biological Products
  • Smart Materials