Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease

Ashish Misra; Edward A Fisher

doi:10.1016/j.stem.2020.06.012

Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease

Cell Stem Cell. 2020 Jul 2;27(1):6-7. doi: 10.1016/j.stem.2020.06.012.

Authors

Ashish Misra¹, Edward A Fisher²

Affiliations

¹ Heart Research Institute, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: ashish.misra@hri.org.au.
² Department of Medicine/Divsion of Cardiology, and the Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: edward.fisher@nyulangone.org.

PMID: 32619519
DOI: 10.1016/j.stem.2020.06.012

Abstract

Many type 2 diabetes patients develop cardiovascular disease (CVD) while some are protected. Toyohara et al. (2020) find that elevated arylacetamide deacetylase (AADAC) expression in vascular smooth muscle cells (dVSMCs) differentiated from patient-derived induced pluripotent stem cells is associated with cardioprotection. AADAC overexpression alters multiple dVSMC properties and decreases murine CVD.

Publication types

Comment

MeSH terms

Animals
Atherosclerosis*
Carboxylic Ester Hydrolases
Cardiovascular Diseases*
Diabetes Mellitus, Type 2*
Humans
Induced Pluripotent Stem Cells*
Mice
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle
Translational Research, Biomedical

Substances

AADAC protein, human
Carboxylic Ester Hydrolases