Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance

Yanjie Ding; Laifang Wang; Huiqiang Wu; Qing Zhao; Shufang Wu

doi:10.1177/1535370220934736

Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance

Exp Biol Med (Maywood). 2020 Aug;245(14):1177-1186. doi: 10.1177/1535370220934736. Epub 2020 Jul 2.

Authors

Yanjie Ding^{1

2}, Laifang Wang², Huiqiang Wu², Qing Zhao², Shufang Wu¹

Affiliations

¹ Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
² Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Henan, Kaifeng 475000, P.R. China.

Abstract

A comparative study of osteoarthritis (OA) and RA mice was implemented to suggest that miR-424 expression was increased in RA, and exosome-miR-424 derived from synovial fibroblasts (SFs-exo) could significantly induce T cells differentiation in which Th17 cells increased and Treg cells decreased via targeting FOXP3. And thus, miR-424 may be a potential therapeutic target for RA.

Keywords: Hypoxia; Th17/Treg cells; exosome; rheumatoid arthritis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arthritis, Rheumatoid / immunology*
Cell Differentiation / immunology
Cells, Cultured
Cytokines / immunology
Exosomes / immunology*
Fibroblasts / immunology*
Forkhead Transcription Factors / immunology
Hypoxia / immunology*
Inflammation / immunology
Male
Mice
Mice, Inbred BALB C
MicroRNAs / immunology
Synovial Membrane / immunology*
T-Lymphocytes, Regulatory / immunology*
Th17 Cells / immunology*

Substances

Cytokines
Forkhead Transcription Factors
MicroRNAs