Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries

Eur J Clin Microbiol Infect Dis. 2020 Dec;39(12):2447-2455. doi: 10.1007/s10096-020-03967-9. Epub 2020 Jul 1.

Abstract

This study compared the laboratory indexes in 40 non-severe COVID-19 patients with those in 57 healthy controls. In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating hormone, growth hormone, and insulin-like growth factor-binding protein 3 significantly decreased, and total protein, albumin, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase, activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer, fibrinogen degradation products, human epididymal protein 4, serum ferritin, and C-reactive protein were elevated. SARS-CoV-2 infection can affect hematopoiesis, hemostasis, coagulation, fibrinolysis, bone metabolism, thyroid, parathyroid glands, the liver, and the reproductive system.

Keywords: COVID-19; Diagnostic value; Laboratory index; Organ injury; SARS-CoV-2.

MeSH terms

  • Adult
  • Betacoronavirus / pathogenicity*
  • Biomarkers / blood
  • Bone and Bones / metabolism
  • Bone and Bones / pathology
  • Bone and Bones / virology
  • C-Reactive Protein / metabolism
  • COVID-19
  • Case-Control Studies
  • China / epidemiology
  • Coronavirus Infections / blood*
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / pathology
  • Cross-Sectional Studies
  • Female
  • Ferritins / blood
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Fibrinolysis
  • Hematopoiesis
  • Hemostasis
  • Humans
  • Liver / metabolism
  • Liver / pathology
  • Liver / virology
  • Male
  • Middle Aged
  • Ovary / metabolism
  • Ovary / pathology
  • Ovary / virology
  • Pandemics*
  • Parathyroid Glands / metabolism
  • Parathyroid Glands / pathology
  • Parathyroid Glands / virology
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / pathology
  • SARS-CoV-2
  • Serum Albumin / metabolism
  • Severity of Illness Index
  • Testis / metabolism
  • Testis / pathology
  • Testis / virology
  • Thyroid Gland / metabolism
  • Thyroid Gland / pathology
  • Thyroid Gland / virology

Substances

  • Biomarkers
  • Fibrin Fibrinogen Degradation Products
  • Serum Albumin
  • fibrin fragment D
  • C-Reactive Protein
  • Ferritins