Secondary Bacterial Infections in Critical Ill Patients With Coronavirus Disease 2019

Yiqi Fu; Qing Yang; Min Xu; Haishen Kong; Hongchao Chen; Yajie Fu; Yake Yao; Hua Zhou; Jianying Zhou

doi:10.1093/ofid/ofaa220

Secondary Bacterial Infections in Critical Ill Patients With Coronavirus Disease 2019

Open Forum Infect Dis. 2020 Jun 5;7(6):ofaa220. doi: 10.1093/ofid/ofaa220. eCollection 2020 Jun.

Authors

Yiqi Fu¹, Qing Yang^{2

3

4}, Min Xu^{2

3}, Haishen Kong^{2

3

4}, Hongchao Chen^{2

3}, Yajie Fu^{2

3}, Yake Yao¹, Hua Zhou¹, Jianying Zhou¹

Affiliations

¹ Department of Respiratory Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
³ Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Secondary bacterial infections occurred in 13.9% (5 of 36) of critical ill patients with coronavirus disease 2019. All 5 patients had been admitted to intensive care unit and received mechanical ventilation before developing bacterial infection. Active surveillance of culture should be performed for critically ill patients. Prevention of nosocomial infection should to be taken seriously.

Keywords: COVID-19; Gram-negative bacilli; antibiotic prophylaxis; bacterial infection; critical ill.