The Cardiorespiratory Network in Healthy First-Degree Relatives of Schizophrenic Patients

Steffen Schulz; Jens Haueisen; Karl-Jürgen Bär; Andreas Voss

doi:10.3389/fnins.2020.00617

The Cardiorespiratory Network in Healthy First-Degree Relatives of Schizophrenic Patients

Front Neurosci. 2020 Jun 16:14:617. doi: 10.3389/fnins.2020.00617. eCollection 2020.

Authors

Steffen Schulz¹, Jens Haueisen², Karl-Jürgen Bär³, Andreas Voss¹

Affiliations

¹ Institute of Innovative Health Technologies (IGHT), University of Applied Sciences, Jena, Germany.
² Institute of Biomedical Engineering and Informatics, Ilmenau University of Technology, Ilmenau, Germany.
³ Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital, Jena, Germany.

Abstract

Impaired heart rate- and respiratory regulatory processes as a sign of an autonomic dysfunction seems to be obviously present in patients suffering from schizophrenia. Since the linear and non-linear couplings within the cardiorespiratory system with respiration as an important homeostatic control mechanism are only partially investigated so far for those subjects, we aimed to characterize instantaneous cardiorespiratory couplings by quantifying the casual interaction between heart rate (HR) and respiration (RESP). Therefore, we investigated causal linear and non-linear cardiorespiratory couplings of 23 patients suffering from schizophrenia (SZO), 20 healthy first-degree relatives (REL) and 23 healthy subjects, who were age-gender matched (CON). From all participants' heart rate (HR) and respirations (respiratory frequency, RESP) were investigated for 30 min under resting conditions. The results revealed highly significant increased HR, reduced HR variability, increased respiration rates and impaired cardiorespiratory couplings in SZO in comparison to CON. SZO were revealed bidirectional couplings, with respiration as the driver (RESP → HR), and with weaker linear and non-linear coupling strengths when RESP influencing HR (RESP → HR) and with stronger linear and non-linear coupling strengths when HR influencing RESP (HR → RESP). For REL we found only significant increased HR and only slightly reduced cardiorespiratory couplings compared to CON. These findings clearly pointing to an underlying disease-inherent genetic component of the cardiac system for SZO and REL, and those respiratory alterations are only clearly present in SZO seem to be connected to their mental emotional states.

Keywords: Network Physiology; cardiorespiratory coupling; partial directed coherence; relatives; schizophrenia; transfer entropy.