The association between ankylosing spondylitis, acute anterior uveitis and HLA-B27: the results of a Swiss family study

Br J Rheumatol. 1988:27 Suppl 2:39-41. doi: 10.1093/rheumatology/xxvii.suppl_2.39.

Abstract

Patients with HLA-B27 positive ankylosing spondylitis (AS) in a Swiss family study developed non-granulomatous acute anterior uveitis (AAU) 11 times more often than their healthy relatives sharing the same HLA-B27 positive haplotype (4.4% versus 0.4%; p less than 0.01) during a period of 6 months.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • HLA Antigens / analysis*
  • HLA Antigens / genetics
  • HLA-B27 Antigen
  • Haplotypes
  • Humans
  • Middle Aged
  • Spondylitis, Ankylosing / complications*
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / immunology
  • Uveitis, Anterior / complications*
  • Uveitis, Anterior / genetics
  • Uveitis, Anterior / immunology

Substances

  • HLA Antigens
  • HLA-B27 Antigen