Clinical utility of apparent diffusion coefficient and diffusion-weighted magnetic resonance imaging for resectability assessment of head and neck tumors with skull base invasion

Takenori Ogawa; Ikuho Kojima; Shun Wakamori; Takuya Yoshida; Takaki Murata; Maya Sakamoto; Akira Ohkoshi; Ayako Nakanome; Hidenori Endo; Toshiki Endo; Hajime Usubuchi; Yukio Katori

doi:10.1002/hed.26336

Clinical utility of apparent diffusion coefficient and diffusion-weighted magnetic resonance imaging for resectability assessment of head and neck tumors with skull base invasion

Head Neck. 2020 Oct;42(10):2896-2904. doi: 10.1002/hed.26336. Epub 2020 Jul 1.

Authors

Takenori Ogawa^{1

2}, Ikuho Kojima^{2

3}, Shun Wakamori^{1

2}, Takuya Yoshida^{1

2}, Takaki Murata^{2

4}, Maya Sakamoto^{2

3}, Akira Ohkoshi^{1

2}, Ayako Nakanome^{1

2}, Hidenori Endo^{2

5}, Toshiki Endo⁵, Hajime Usubuchi⁶, Yukio Katori^{1

2}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital, Sendai, Japan.
² Head and Neck Cancer Center, Tohoku University Hospital, Sendai, Japan.
³ Department of Oral Diagnosis, Tohoku University Hospital, Sendai, Japan.
⁴ Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Japan.
⁵ Department of Neurosurgery, Tohoku University Hospital, Sendai, Japan.
⁶ Department of Pathology, Tohoku University Hospital, Sendai, Japan.

PMID: 32608548
DOI: 10.1002/hed.26336

Abstract

Background: The usefulness of apparent diffusion coefficient (ADC) and diffusion-weighted magnetic resonance imaging (DWI) in the detection of malignant tumors has been reported. The purpose of this study is to clarify the role of ADC and DWI for diagnosis of skull base tumors.

Methods: A total of 27 patients with head and neck tumors with skull base invasions undergoing skull base surgery were enrolled in this study. Pathological findings of dural invasion and bone invasion were compared with the diagnostic imaging.

Results: Advanced magnetic resonance imaging techniques revealed that ADC values in regions of pathological bone and dural invasions were significantly lower than in regions of no invasion. The area under the curve of ADC in bone invasions and dural invasions were 0.957 and 0.894, respectively.

Conclusions: Our findings indicate that ADC and DWI are useful tools for the diagnosis of head and neck tumors with skull base invasion.

Keywords: ADC; DWI; MRI; head and neck cancer; skull base tumor.

MeSH terms

Diffusion Magnetic Resonance Imaging
Head and Neck Neoplasms* / diagnostic imaging
Head and Neck Neoplasms* / surgery
Humans
Magnetic Resonance Imaging
Skull Base / diagnostic imaging
Skull Base / surgery
Skull Base Neoplasms* / diagnostic imaging
Skull Base Neoplasms* / surgery