Heterogeneity of the response of venous smooth muscle to arterial endothelium-derived relaxing factor (EDRF) in respect of the role of nitric oxide

Y P Vedernikov; T Gräser; N Tiedt; A M Vikhert

doi:10.1007/BF01907265

Heterogeneity of the response of venous smooth muscle to arterial endothelium-derived relaxing factor (EDRF) in respect of the role of nitric oxide

Basic Res Cardiol. 1988 Mar-Apr;83(2):122-7. doi: 10.1007/BF01907265.

Authors

Y P Vedernikov¹, T Gräser, N Tiedt, A M Vikhert

Affiliation

¹ Department of Human Cardiovascular Pathology, All-Union Cardiology Research Centre, Academy of Medical Sciences, Moscow, U.S.S.R.

PMID: 3260772
DOI: 10.1007/BF01907265

Abstract

In bioassay and organ bath experiments, the responses of different canine venous preparations to arterial and their own EDRF were studied. Vena jugularis, vena femoralis and vena mesenterica relaxed on both EDRFs released by acetylcholine. Vena saphena, venae cordis and vena portae did not show endothelium-dependent dilation, either under bioassay or in organ bath experiments. All the veins tested relaxed completely after sodium nitroprusside administration. The identity of EDRF and nitric oxide is not confirmed by this study.

MeSH terms

Animals
Biological Products / pharmacology*
Dogs
Endothelium, Vascular / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects*
Nitric Oxide*
Vasodilator Agents / pharmacology*
Veins / drug effects*

Substances

Biological Products
Vasodilator Agents
Nitric Oxide