A Feasibility Study for 3D-printed Poly(methyl methacrylate)-resin Tracheostomy Tube Using a Hamster Cheek Pouch Model

In Vivo. 2020 Jul-Aug;34(4):1749-1758. doi: 10.21873/invivo.11968.

Abstract

Background/aim: A three-dimensional (3D) printed tracheostomy tube has potential application for patients who require a specialized tube. The aim of this study was to evaluate the characteristics of various 3D printing materials and determine their use in producing 3D-printed tracheostomy tube.

Materials and methods: Mechanical, chemical, and microbiological in vivo changes in the scaffolds were analyzed using a hamster cheek pouch (HCP) model.

Results: The poly methyl methacylate (PMMA)-resin showed superior pre- and post-insertion mechanical properties and a relatively consistent lower biofilm formation compared with other scaffolds. PMMA-resin was successfully 3D-printed with dimensional accuracy without a support system. The use of a 3D-printed PMMA tracheostomy tube in a rabbit trachea showed no definite signs of infection, allergy or foreign body reaction.

Conclusion: PMMA-resin can be proposed as an alternative for a 3D-printed tracheostomy tube material. In addition, we suggest HCPs as an in vivo model for evaluating indwelling medical devices.

Keywords: 3D printing; hamster; resin; tracheostomy; tube.

MeSH terms

  • Animals
  • Cheek
  • Cricetinae
  • Feasibility Studies
  • Humans
  • Polymethyl Methacrylate*
  • Printing, Three-Dimensional
  • Rabbits
  • Tracheostomy*

Substances

  • Polymethyl Methacrylate