Introduction: The association between interleukin(IL)-17A and IL-17 F gene polymorphism with rheumatoid arthritis (RA) were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17 F gene polymorphism with RA.
Methods: We searched Medline up to February 2020. Meta-analyses were performed for the comparisons of allele and multiple genetic models, including dominant, recessive, heterozygous, and homozygous models using fixed or random effects models. Odds ratios (OR) with 95% confidence intervals (95%CI) were utilized to assess the potential relationship.
Results: A total of 2315 confirmed cases and 2342 controls were included from eligible 10 case-controls studies. Meta analysis suggested that rs2275913 G allele increased the risk of RA in Caucasians (G vs A: OR = 1.14, 95% CI = 1.00-1.29, P = .044), but not in Mongolians (P > .05). Pooled analysis suggested that a significant associations between rs763780 C allele with RA susceptibility (C vs T: OR = 1.83, 95% CI = 1.13-2.97, P = .014). Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to RA risk in two races (P < .001). TSA plot revealed that the present study sufficient to draw a conclusion.
Conclusions: This meta-analysis demonstrates IL-17A and IL-17 F genes play a significant role in RA, but its role in Mongolian populations needs further exploration.
Keywords: IL-17; meta-analysis; polymorphism; rheumatoid arthritis.