Multimodality Imaging Features of a Misleading Sacral Giant Cell Tumor in 18F-FDG PET/CT, Bone Scan, and MRI

Clin Nucl Med. 2020 Oct;45(10):800-801. doi: 10.1097/RLU.0000000000003148.

Abstract

We report the case of an asymptomatic 66-year-old woman referred for initial staging of an invasive ductal breast carcinoma. Initial workup incidentally revealed a bone tumor of right sacral wing corresponding to a giant cell tumor (GCT). We present the imaging characteristics of GCT on Tc-HDP bone scan (doughnut sign), F-FDG PET/CT (intense and heterogeneous uptake of a prominent geographic lytic lesion with partial rupture of cortical), and MRI (hyposignal with gadolinium enhancement on T1-weighted images and heterogeneous hypersignal on T2-weighted images). GCT is a benign but locally aggressive primary bone tumor, constituting a pitfall and diagnostic challenge.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / pathology
  • Female
  • Fluorodeoxyglucose F18*
  • Giant Cell Tumors / diagnostic imaging*
  • Giant Cell Tumors / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Positron Emission Tomography Computed Tomography*
  • Sacrum / diagnostic imaging*

Substances

  • Fluorodeoxyglucose F18