Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk

Ivone F O C Nunes; Ana A C M Cavalcante; Marcus V O B Alencar; Marcos D F Carvalho; José L R Sarmento; Nayra S C C A Teixeira; Adriana A Paiva; Lídia R Carvalho; Leopoldo F M Nascimento; Maria S P Cruz; Marcelo M Rogero; Andréia C B Lima; Cecilia M R G Carvalho

doi:10.1093/advances/nmaa076

Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk

Adv Nutr. 2020 Sep 1;11(5):1211-1220. doi: 10.1093/advances/nmaa076.

Affiliations

¹ Post-Graduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.
² Post-Graduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.
³ Department of Animal Science, Federal University of Piauí, Teresina, Piauí, Brazil.
⁴ Post-Graduate Program in Animal Science, Federal University of Piauí, Teresina, Piauí, Brazil.
⁵ Faculty of Public Health, University of São Paulo, São Paulo, São Paulo, Brazil.
⁶ Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.

Abstract

The association between FokI polymorphism in the vitamin D receptor (VDR) gene and susceptibility to arterial hypertension (HT) is controversial. Thus, we evaluated the relation between FokI and HT according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using MEDLINE® (Medical Literature Analysis and Retrieval System Online)/PubMed, Scopus, and Cochrane Library CENTRAL databases. Data from case-control studies, including the number of participants, age, 25-hydroxyvitamin D concentrations, systolic and diastolic blood pressure values, FokI allele, and genotype frequency were extracted by 2 independent authors and OR was calculated with the 95% CI to assess the strength of the association between the FokI variant and odds of HT. In general and subgroup analyses, we used allelic (f compared with F), common (ff compared with FF + Ff), risk (ff + Ff compared with FF), and additive (ff compared with FF) models. Six case-control studies including 3140 cases and 3882 controls were reviewed in the meta-analysis. Global assessment revealed a correlation between FokI and reduced odds of HT in the additive/homozygote model (ff compared with FF; OR: 0.65; 95% CI: 0.45-0.94) and common/recessive model (ff compared with FF + Ff; OR: 0.75; 95% CI: 0.57-0.99). In Asian subjects, there was a significant reduction in the odds of HT in additive (ff compared with FF; OR: 0.84; 95% CI: 0.73-0.98) and risk models (ff + Ff compared with FF; OR: 0.87, 95% CI: 0.78-0.97), in particular, for Indians (South). In Africans, the statistically significant association occurred in the additive and common models. Allele f in the FokI polymorphism of the VDR gene was associated with reduced odds of HT in the general population based on the risk model. Thus, nutritional genomics can help understand the influence of nutrition on metabolic homeostasis pathways and the clinical consequences of hypertension. This study shows the need for healthy, anti-inflammatory, and antioxidant compounds to prevent or treat chronic complications.

Keywords: 1,25(OH)2D; 25(OH)D; cardiovascular disease; renin; rs10735810.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People
Case-Control Studies
Genetic Predisposition to Disease
Humans
Hypertension* / genetics
Polymorphism, Genetic
Receptors, Calcitriol* / genetics

Substances

Receptors, Calcitriol