Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats

Ana Miriã Pacífico; Samuel P Batista; Fernanda T Ribeiro; Pedro B Dos Santos; Gabriel Bruno Silveira; Bruna Pascarelli Pedrico do Nascimento; Eduardo Dias Junior; Geraldo Henrique L Barbosa; Miriam Oliveira Ribeiro; Sergio Gomes da Silva; Roberta M Cysneiros

doi:10.1016/j.dib.2020.105819

Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats

Data Brief. 2020 Jun 7:31:105819. doi: 10.1016/j.dib.2020.105819. eCollection 2020 Aug.

Affiliations

¹ Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil.
² Hospital do Câncer de Muriaé - Fundação Cristiano Varella, Muriaé, Brazil.
³ Centro Universitário UNIFAMINAS, Muriaé, Brazil.

Abstract

Early-life status epilepticus produces deficit in social interaction and vocalization, enhances anxiety, no cognitive impairment and alters functional connectivity within the hippocampus (CA3-CA1) and between the hippocampus and prefrontal cortex [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], but the underlying mechanisms remain unknown. This data article contains behavioral and molecular data of the adult male Wistar rats subjected to early life pilocarpine-induced seizures. Animal's behaviors were assessed to social memory and social motivation, working and reference memories and cognitive flexibility. The brain tissues (hypothalamus, hippocampus, amygdala, and striatum) were probed to gene and protein expression of molecules related to social behavior, reward system and synaptic function.

Keywords: Cognition; Early-life status epilepticus; Motivation; Oxytocin; Pilocarpine; Sociability.