Changes of Laboratory Cardiac Markers and Mechanisms of Cardiac Injury in Coronavirus Disease 2019

Biomed Res Int. 2020 May 26:2020:7413673. doi: 10.1155/2020/7413673. eCollection 2020.

Abstract

Some patients with coronavirus disease 2019 (COVID-19) show abnormal changes in laboratory myocardial injury markers, suggesting that patients with myocardial injury have a higher mortality rate than those without myocardial injury. This article reviews the possible mechanism of myocardial injury in patients with COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the patients with COVID-19 in aspects of direct infection of myocardial injury, specific binding to functional receptors on cardiomyocytes, and immune-mediated myocardial injury. During hospitalization, the monitoring of laboratory myocardial injury markers in patients of COVID-19 should be strengthened.

Publication types

  • Review

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus*
  • Biomarkers / blood
  • Biomarkers / metabolism
  • COVID-19
  • Coronavirus Infections / blood*
  • Coronavirus Infections / complications*
  • Coronavirus Infections / metabolism
  • Cytokines / blood
  • Cytokines / immunology
  • Heart Injuries / blood*
  • Heart Injuries / etiology*
  • Heart Injuries / metabolism
  • Humans
  • Inflammation Mediators / blood
  • Inflammation Mediators / immunology
  • Models, Cardiovascular
  • Models, Immunological
  • Myocytes, Cardiac / immunology
  • Myocytes, Cardiac / metabolism
  • Pandemics
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / metabolism
  • SARS-CoV-2

Substances

  • Biomarkers
  • Cytokines
  • Inflammation Mediators
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2