Hemoglobin S/OArab: Retinal Manifestations of a Rare Hemoglobinopathy

Riley Sanders; Victoria Ly; Kinza Ahmad; Jesse Swift; Ahmed Sallam; Sami Uwaydat

doi:10.1159/000507879

Hemoglobin S/O_Arab: Retinal Manifestations of a Rare Hemoglobinopathy

Case Rep Ophthalmol. 2020 May 27;11(2):189-195. doi: 10.1159/000507879. eCollection 2020 May-Aug.

Authors

Riley Sanders¹, Victoria Ly², Kinza Ahmad¹, Jesse Swift^{1

3}, Ahmed Sallam¹, Sami Uwaydat¹

Affiliations

¹ Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
² College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
³ Southwest Eye Care, Albuquerque, New Mexico, USA.

Abstract

Hemoglobin S/O_Arab (Hgb S/O_Arab) disease is a rare hemoglobinopathy which presents similarly to sickle cell retinopathy, with only three prior reports that describe associated retinal findings. In this report, we present ophthalmic examination findings in 2 patients with Hgb S/O_Arab. One patient exhibited peripheral ischemia and sunburst lesions without neovascular disease, and the other patient developed proliferative retinopathy of both eyes and multiple posterior-pole branch retinal artery occlusions in one eye. To our knowledge, this is the first case of retinal arterial occlusive disease in Hgb S/O_Arab, and the first report of fundus autofluorescence and OCT angiography in Hgb/O_Arab retinopathy.

Keywords: Hemoglobin S/OArab; Hemoglobinopathy; Retinal ischemia; Sickle cell retinopathy.

Publication types

Case Reports