The pharmacological and biological roles of eriodictyol

Arch Pharm Res. 2020 Jun;43(6):582-592. doi: 10.1007/s12272-020-01243-0. Epub 2020 Jun 27.

Abstract

Eriodictyol is a flavonoid in the flavanones subclass. It is abundantly present in a wide range of medicinal plants, citrus fruits, and vegetables that are considered to have potential health importance. Having the considerable medicinal properties, eriodictyol has been predicted to clarify the mode of action in various cellular and molecular pathways. Evidence for the existing therapeutic roles of eriodictyol includes antioxidant, anti-inflammatory, anti-cancer, neuroprotective, cardioprotective, anti-diabetic, anti-obesity, hepatoprotective, and miscellaneous. Therefore, this review aims to present the recent evidence regarding the mechanisms of action of eriodictyol in different signaling pathways in a specific disease condition. In view of the immense therapeutic effects, eriodictyol may serve as a potential drug source to enhance community health standards.

Keywords: Eriodictyol; Flavonoid; Health disorders; Oxidative stress; Therapeutic benefits.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Flavanones / chemistry
  • Flavanones / pharmacology*
  • Humans
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology
  • Molecular Conformation
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Obesity Agents
  • Antineoplastic Agents
  • Antioxidants
  • Flavanones
  • Hypoglycemic Agents
  • Neuroprotective Agents
  • eriodictyol