Controllable synthesis of versatile mesoporous organosilica nanoparticles as precision cancer theranostics

Yaya Cheng; Xiangyu Jiao; Wenpei Fan; Zhen Yang; Yongqiang Wen; Xiaoyuan Chen

doi:10.1016/j.biomaterials.2020.120191

Controllable synthesis of versatile mesoporous organosilica nanoparticles as precision cancer theranostics

Biomaterials. 2020 Oct:256:120191. doi: 10.1016/j.biomaterials.2020.120191. Epub 2020 Jun 20.

Authors

Yaya Cheng¹, Xiangyu Jiao², Wenpei Fan³, Zhen Yang⁴, Yongqiang Wen⁵, Xiaoyuan Chen⁶

Affiliations

¹ School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing, 100083, PR China; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
² School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing, 100083, PR China.
³ State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: wenpei.fan@cpu.edu.cn.
⁴ Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
⁵ School of Chemistry and Biological Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing, 100083, PR China. Electronic address: wyq_wen@iccas.ac.cn.
⁶ Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: shawn.chen@nih.gov.

PMID: 32593907
DOI: 10.1016/j.biomaterials.2020.120191

Abstract

Despite the advantages of mesoporous silica nanoparticles (MSNs) in drug delivery, the inherent non-biodegradability seriously impedes the clinical translation of inorganic MSNs, so the current research focus has been turned to mesoporous organosilica nanoparticles (MONs) with higher biocompatibility and easier biodegradability. Recent remarkable advances in silica fabrication chemistry have catalyzed the emergence of a library of MONs with various structures and functions. This review will summarize the latest state-of-the-art studies on the precise control of morphology, structure, framework, particle size and pore size of MONs, which enables the precise synthesis of MONs with suitable engineering for precision stimuli-responsive drug delivery/release, bioimaging and synergistic therapy. Besides, the potential challenges about the future development of MONs are also outlooked with the intention of attracting more researchers to promote the clinical translation of MONs.

Keywords: Controllable synthesis; Mesoporous organosilica nanoparticles; Nanomedicine; Precision cancer theranostics; Tumor microenvironment responsiveness.

Published by Elsevier Ltd.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Carriers
Drug Delivery Systems
Humans
Nanoparticles*
Neoplasms* / diagnosis
Neoplasms* / drug therapy
Porosity
Precision Medicine
Silicon Dioxide

Substances

Drug Carriers
Silicon Dioxide