In addition to human activities, this study found that topography is also an important factor affecting land surface temperature (LST). In this paper, based on Landsat 8 OLI/TIRS remote sensing images, a radiative transfer model was adopted to retrieve the LST, and a maximum likelihood method was used to remove artificial environmental interference factors, such as water bodies and built-up lands. This paper aims to analyze the influence of topographic factors, such as elevation, slope, aspect and shaded relief, on the LST of Hangzhou. By means of a statistical analysis, we obtained the quantitative relationship between these factors and constructed a multiple linear regression model of terrain factors and LST. The research revealed the following findings: (1) in the study area, elevation and slope are negatively correlated with LST, and all the factors have linear relationships with LST. (2) The relationship between aspect and LST is not significant, and high values of LST are found on the southern, southeastern and southwestern slopes; the lowest values are found on the northern slopes. (3) There is a significant linear relationship between the values of the shaded relief map and LST, and the more shadows there are, the lower the LST value will be. (4) After comprehensive analysis of the influence of the abovementioned topographic factors on the LST, it is found that shaded relief has the greatest contribution and is positively correlated with LST. The influence of shaded relief on surface thermal environment should be paid more attention in the process of surface thermal environment work. The assessment of the influence degree of shaded relief and surface thermal environment should be the premise and basis for many other studies.