Role of Microbiota-Derived Bile Acids in Enteric Infections

Cell. 2020 Jun 25;181(7):1452-1454. doi: 10.1016/j.cell.2020.05.033.

Abstract

In this issue of Cell, Alavi et al. report that infection by Vibrio cholerae is blocked by gut microbiome-mediated hydrolysis of bile acids. Cholera therefore joins amebic dysentery and Clostridioides difficile colitis as enteric infections profoundly influenced by the microbiome's impact on bile acid metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bile Acids and Salts
  • Cholera*
  • Gastrointestinal Microbiome*
  • Humans
  • Microbiota*
  • Vibrio cholerae*

Substances

  • Bile Acids and Salts