The memory of the fatty acid system

Abstract

Mental memory system has sensory memory, short-term memory, working memory, and long-term memory. Working memory "keeps things in mind in parallel" when performing complex tasks. Similar aspects can be found for immunological memory. However, there exists another one, the memory of the fatty acid system. This article shows sensory memory of the fatty acid system, which is the perception apparatus of small intestine enterocytes (CD36, SR-B1, FATP4, FABP1, FABP2) and hepatocytes. In these cells, the fatty acid short-term memory is located, consisting of a cytoplasmic lipid droplet cycle. Similar like a working memory in the brain, the short-term memory of enterocytes and hepatocytes use parallel processing and recourse to long-term fatty acid memory. The fatty acid long-term memory is far away from these primary points of uptake. It is located in the adipocyte and in cellular membranes. The process of building a fatty acid memory is described with constructs like sensing environmental material, encoding, consolidation, long-term storage, retrieval, re-encoding, re-consolidation, and renewed long-term storage. The article illustrates the dynamics of building a fatty acid memory, the information content of fatty acids including the code, the roles of fatty acids in the body, and a new understanding of the expression "you are what you eat". The memory of the fatty acid system, plays a decisive role in integrating environmental signals over time (diet and microbiome).

Keywords: Adipocyte; Dynamics of memory; Enterocyte; Fatty acids; Hepatocyte; Memory.