Demographic characteristics and neuropsychological assessments of subjective cognitive decline (SCD) (plus)

Lixiao Hao; Yu Sun; Yun Li; Jieyu Wang; Zichen Wang; Zhongying Zhang; Zhanyun Wei; Ge Gao; Jianguo Jia; Yue Xing; Ying Han

doi:10.1002/acn3.51068

Demographic characteristics and neuropsychological assessments of subjective cognitive decline (SCD) (plus)

Ann Clin Transl Neurol. 2020 Jun;7(6):1002-1012. doi: 10.1002/acn3.51068.

Authors

Lixiao Hao^{1

2}, Yu Sun³, Yun Li², Jieyu Wang², Zichen Wang², Zhongying Zhang², Zhanyun Wei², Ge Gao², Jianguo Jia⁴, Yue Xing⁵, Ying Han^{3

6

7}

Affiliations

¹ Department of General Practice, XuanWu Hospital of Capital Medical University, Beijing, China.
² Department of Geriatrics, XuanWu Hospital of Capital Medical University, Beijing, China.
³ Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
⁴ Department of General Surgery, XuanWu Hospital of Capital Medical University, Beijing, China.
⁵ Radiological Sciences, Division of Clinical Neuroscience, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
⁶ National Clinical Research Center for Geriatric Disorders, Beijing, China.
⁷ Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.

Abstract

Background: Since SCD (plus) was standardized, little is known about its demographic characteristics and its outcomes of neuropsychological assessments, including the SCD questionnaire 9 (SCD-Q9).

Objective: To characterize SCD (plus) by comparing the neuropsychological features among its subgroups and with normal controls (NC). Also, to explore its demographics and to understand the relation of the chief complaints and the scores of SCD-Q9.

Methods: Multistage stratified cluster random sampling was conducted to select participants. As a result, 84 NC and 517 SCD (plus) were included. SCD (plus) was further classified into several subgroups (SCD-C: concerned cognitive decline; SCD-F: complaints about SCD within the past five years; SCD-P: feeling performance being not as good as their peers; SCD+: presented> 3 of SCD (plus) features; SCD-: presented ≤ 3 of SCD (plus) features (see the diagnostic criteria for the details)) and between-group comparisons of neuropsychological scores were conducted. Point-biserial correlation and binary logistic regression analyses were performed to investigate the demographic characteristics of its subgroups. Finally, Spearman correlation was used to better understand the relation of SCD (plus) to SCD-Q9.

Results: (1) Scores of AVLT-LR (AVLT-LR: Auditory Verbal Learning Test-Long Delayed Recall) and MoCA-B (MoCA: Montreal Cognitive Assessment-Basic) were lower in the SCD-P group than those in the NC group, and the SCD+ group scored lower in the MoCA-B and CDT(CDT: Clock Drawing Test) than the SCD- group. (2) Females were more concerned than male participants. Individuals with lower education level felt that their cognitive performance were worse than their peers. Also, younger people might express concerns more than the more elderly. People who had complaints of SCD-P might be more likely to report SCD-C, but less likely to report SCD-F. (3) Positive correlations were found between the chief complaints of SCD (plus) and some items of SCD-Q9.

Conclusions: SCD (plus) may be related to demographic factors. Individuals with SCD (plus) already exhibited cognitive impairment, which can be detected by SCD-Q9.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Aged
Aged, 80 and over
Aging / physiology*
Cognitive Dysfunction / diagnosis*
Cognitive Dysfunction / physiopathology*
Diagnostic Self Evaluation
Female
Humans
Male
Middle Aged
Neuropsychological Tests*
Sex Factors

Grants and funding

This work was funded by National Key Research and Development Program of China grant 2018YFC1312000; National Natural Science Foundation of China grant 61633018.