Biotinylated platinum(ii) metallacage towards targeted cancer theranostics

Xingchen Wang; Qi Su; Zeyuan Zhang; Jin Yang; Yanmin Zhang; Mingming Zhang

doi:10.1039/d0cc03824e

Biotinylated platinum(ii) metallacage towards targeted cancer theranostics

Chem Commun (Camb). 2020 Jul 28;56(60):8460-8463. doi: 10.1039/d0cc03824e.

Authors

Xingchen Wang¹, Qi Su², Zeyuan Zhang¹, Jin Yang³, Yanmin Zhang², Mingming Zhang¹

Affiliations

¹ State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P. R. China. mingming.zhang@xjtu.edu.cn.
² School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P. R. China. zhang2008@mail.xjtu.edu.cn.
³ Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.

PMID: 32583830
DOI: 10.1039/d0cc03824e

Abstract

A biotinylated metallacage was prepared via metal-coordination-driven self-assembly, combining fluorescence, anti-cancer and targeted properties into a single entity. The metallacage was successfully employed for targeted cell imaging and therapy, offering a platform for cancer theranostics.

MeSH terms

Biotin / chemistry*
Cell Line, Tumor
Cell Survival / drug effects
Coordination Complexes / chemistry
Coordination Complexes / pharmacology
Coordination Complexes / therapeutic use
Fluorescent Dyes / chemistry
Humans
Microscopy, Confocal
Neoplasms / diagnostic imaging
Neoplasms / drug therapy
Platinum / chemistry*
Theranostic Nanomedicine*

Substances

Coordination Complexes
Fluorescent Dyes
Platinum
Biotin