Intact Auditory Cortical Cross-Frequency Coupling in Early and Chronic Schizophrenia

Nicholas Murphy; Nithya Ramakrishnan; Christopher P Walker; Nicola R Polizzotto; Raymond Y Cho

doi:10.3389/fpsyt.2020.00507

Intact Auditory Cortical Cross-Frequency Coupling in Early and Chronic Schizophrenia

Front Psychiatry. 2020 Jun 4:11:507. doi: 10.3389/fpsyt.2020.00507. eCollection 2020.

Authors

Nicholas Murphy^{1

2}, Nithya Ramakrishnan^{1

2}, Christopher P Walker³, Nicola R Polizzotto⁴, Raymond Y Cho^{1

2

5}

Affiliations

¹ Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States.
² Research Service Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, United States.
³ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
⁴ Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States.
⁵ Menninger Clinic, Houston, TX, United States.

Abstract

Background: Previous work has identified a hierarchical organization of neural oscillations that supports performance of complex cognitive and perceptual tasks, and can be indexed with phase-amplitude coupling (PAC) between low- and high-frequency oscillations. Our aim was to employ enhanced source localization afforded by magnetoencephalography (MEG) to expand on earlier reports of intact auditory cortical PAC in schizophrenia and to investigate how PAC may evolve over the early and chronic phases of the illness.

Methods: Individuals with early schizophrenia (n=12) (≤5 years of illness duration), chronic schizophrenia (n=16) (>5 years of illness duration) and healthy comparators (n = 17) performed the auditory steady state response (ASSR) to 40, 30, and 20 Hz stimuli during MEG recordings. We estimated amplitude and PAC on the MEG ASSR source localized to the auditory cortices.

Results: Gamma amplitude during 40-Hz ASSR exhibited a significant group by hemisphere interaction, with both patient groups showing reduced right hemisphere amplitude and no overall lateralization in contrast to the right hemisphere lateralization demonstrated in controls. We found significant PAC in the right auditory cortex during the 40-Hz entrainment condition relative to baseline, however, PAC did not differ significantly between groups.

Conclusions: In the current study, we demonstrated an apparent sparing of ASSR-related PAC across phases of the illness, in contrast with impaired cortical gamma oscillation amplitudes. The distinction between our PAC and evoked ASSR findings supports the notion of separate but interacting circuits for the generation and maintenance of sensory gamma oscillations. The apparent sparing of PAC in both early and chronic schizophrenia patients could imply that the neuropathology of schizophrenia differentially affects these mechanisms across different stages of the disease. Future studies should investigate the distinction between PAC during passive tasks and more cognitively demanding task such as working memory so that we can begin to understand the influence of schizophrenia neuropathology on the larger framework for modulating neurocomputational capacity.

Keywords: ASSR = auditory steady-state response; Cross Frequency Coupling (CFC); biomarker; magnetoencephalagraphy (MEG); phase amplitude coupling; schziophrenia.