Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure

Lei Gao; Andrew S P Lim; Patricia M Wong; Arlen Gaba; Longchang Cui; Lei Yu; Aron S Buchman; David A Bennett; Kun Hu; Peng Li

doi:10.2147/NSS.S253757

Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure

Nat Sci Sleep. 2020 May 27:12:299-307. doi: 10.2147/NSS.S253757. eCollection 2020.

Authors

Lei Gao^{1

2}, Andrew S P Lim³, Patricia M Wong⁴, Arlen Gaba², Longchang Cui², Lei Yu⁵, Aron S Buchman⁵, David A Bennett⁵, Kun Hu^{2

6}, Peng Li^{2

6}

Affiliations

¹ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
² Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
³ Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, USA.
⁴ Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
⁵ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
⁶ Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Study objectives: Heart failure has previously been linked to sleep disorders that are often associated with frequent disturbances to human rest/activity patterns. We tested whether fragmentation of sustained rest/activity patterns derived from actigraphic recordings at baseline predicts incident heart failure in community-based elderly individuals.

Methods: We studied 1099 community-based elderly adults participating in the Rush Memory and Aging Project who had baseline motor activity monitoring up to 11 days and were followed annually for up to 14 years. Fragmentation was assessed using previously validated indexes, derived from the probability of transitions once sustained rest or activity has been established. Heart failure was recorded via a clinical interview during the annual follow-up. Cox proportional hazards models were constructed to examine the relationship between rest fragmentation index and incident heart failure. Covariates grouped in terms of demographics, lifestyle factors and co-morbidities and cardiovascular risk factors/diseases were included.

Results: Increased rest fragmentation (but not activity fragmentation) was associated with higher risk for incident heart failure. Specifically, a subject with a rest fragmentation at the 90th percentile showed a 57% increased risk of developing incident heart failure compared to a subject at the 10th percentile in this cohort. This effect was equivalent to that of being over a decade older. These observations were consistent after adjusting for all covariates.

Conclusion: Increased rest fragmentation, a potential surrogate for sleep fragmentation, is independently associated with a higher risk of developing heart failure in community-based elderly adults during up to 14 years of follow-up. Further work is required to examine the specific contributions from daytime napping versus nighttime sleep periods in the elderly, as well as the underlying autonomic and cardio-dynamic pathways that may explain the effects on heart function.

Keywords: heart failure; mobile health; sleep fragmentation; unobtrusive monitoring.

Abstract

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