Inhibition of placental CYP19A1 activity remains as a valid hypothesis for 46,XX virilization in P450 oxidoreductase deficiency

Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14632-14633. doi: 10.1073/pnas.2003154117. Epub 2020 Jun 23.

Authors

Christa E Flück^{1

2}, Shaheena Parween^{1

2}, Maria Natalia Rojas Velazquez^{1

2}, Amit V Pandey^{3

2}

Affiliations

¹ Pediatric Endocrinology, Diabetology, and Metabolism, University Children's Hospital, 3010 Bern, Switzerland.
² Department of Biomedical Research, University of Bern, 3008 Bern, Switzerland.
³ Pediatric Endocrinology, Diabetology, and Metabolism, University Children's Hospital, 3010 Bern, Switzerland; amit@pandeylab.org.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adrenal Hyperplasia, Congenital*
Aromatase
Female
Humans
Oxidation-Reduction
Oxidoreductases
Pregnancy
Virilism*

Substances

Oxidoreductases
Aromatase
CYP19A1 protein, human