Advances in Understanding CREB Signaling-Mediated Regulation of the Pathogenesis and Progression of Epilepsy

Guangming Wang; Zhanpeng Zhu; Dahai Xu; Lichao Sun

doi:10.1016/j.clineuro.2020.106018

Advances in Understanding CREB Signaling-Mediated Regulation of the Pathogenesis and Progression of Epilepsy

Clin Neurol Neurosurg. 2020 Sep:196:106018. doi: 10.1016/j.clineuro.2020.106018. Epub 2020 Jun 15.

Authors

Guangming Wang¹, Zhanpeng Zhu¹, Dahai Xu², Lichao Sun³

Affiliations

¹ Department of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
² Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
³ Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, 130021, Jilin, China. Electronic address: sunlichao5@sina.com.

PMID: 32574967
DOI: 10.1016/j.clineuro.2020.106018

Abstract

Recent studies have indicated that the transcription factor cyclic adenosine monophosphate response element binding protein (CREB) is involved in the etiology of epilepsy. With regard to its transcriptional regulation, CREB phosphorylation is critical for the transmission of multiple extracellular signals, which implicates the activation of downstream target genes in the pathogenesis and progression of epilepsy. This review mainly focuses on recent discoveries of associations between the molecular and structural characteristics of CREB as well as the related CREB signaling pathway and epilepsy.

Keywords: CREB; Epilepsy; Pathogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cyclic AMP Response Element-Binding Protein / metabolism*
Disease Progression
Epilepsy / etiology*
Epilepsy / metabolism
Humans
Phosphorylation
Signal Transduction / physiology*

Substances

Cyclic AMP Response Element-Binding Protein