wERKing the Waves in Collective Cell Migration

Yan Yun Ignacius Tay; Yusuke Toyama

doi:10.1016/j.devcel.2020.06.002

wERKing the Waves in Collective Cell Migration

Dev Cell. 2020 Jun 22;53(6):621-622. doi: 10.1016/j.devcel.2020.06.002.

Authors

Yan Yun Ignacius Tay¹, Yusuke Toyama²

Affiliations

¹ Mechanobiology Institute, Singapore 117411, Singapore.
² Mechanobiology Institute, Singapore 117411, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address: dbsty@nus.edu.sg.

PMID: 32574589
DOI: 10.1016/j.devcel.2020.06.002

Abstract

It remains unclear how intercellular force transmission is coupled with intracellular biochemical signaling to achieve collective cell migration. In this issue of Developmental Cell, Hino et al. demonstrate that intracellular ERK signaling propagates as waves across a tissue and couples with intercellular mechano-transduction to direct epithelial cell migration.

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MeSH terms

Cell Movement
Signal Transduction*