Targeted protection of proximal tubular cells by nanoparticle-enhanced delivery of a TLR9-antagonist

Zoltán H Endre; Jonathan H Erlich

doi:10.1016/j.kint.2020.04.024

Targeted protection of proximal tubular cells by nanoparticle-enhanced delivery of a TLR9-antagonist

Kidney Int. 2020 Jul;98(1):48-50. doi: 10.1016/j.kint.2020.04.024.

Authors

Zoltán H Endre¹, Jonathan H Erlich²

Affiliations

¹ Department of Nephrology, Prince of Wales Hospital, Sydney, Australia; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia. Electronic address: z.endre@unsw.edu.au.
² Department of Nephrology, Prince of Wales Hospital, Sydney, Australia; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.

PMID: 32571488
DOI: 10.1016/j.kint.2020.04.024

Abstract

The kidney target site for injury that leads to acute kidney injury (AKI) is the proximal tubule. Nanoparticle-encapsulation enhanced delivery of a selective Toll-like receptor 9 antagonist to mouse proximal tubules and attenuated experimental ischemia-reperfusion injury in a mouse model of AKI.

MeSH terms

Acute Kidney Injury* / chemically induced
Acute Kidney Injury* / prevention & control
Animals
Kidney Tubules, Proximal
Mice
Nanoparticles*
Reperfusion Injury* / prevention & control
Toll-Like Receptor 9

Substances

Tlr9 protein, mouse
Toll-Like Receptor 9