Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: https://doi.org/10.1111/febs.15335.
Keywords: Mycobacterium tuberculosis; AAA+ protease complex; ClpCP; N-degrons; adaptor proteins; antibiotic target; proteolysis.
© 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.