Abstract
Age-associated reduction in endothelial nitric oxide (NO) synthesis contributes to the development of cardiovascular diseases and sarcopenia. L-Citrulline is a precursor of NO with the ability to improve vascular function and muscle protein synthesis. We hypothesize that vascular and muscular benefits associated with oral L-citrulline supplementation might be augmented by concomitant supplementation with exercise training in older adults.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / physiology*
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Arginine / blood
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Biological Availability
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Body Mass Index
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Citrulline / administration & dosage*
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Dietary Supplements*
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Endothelium, Vascular / physiology
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Endothelium, Vascular / physiopathology
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Exercise / physiology*
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Humans
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Muscle Proteins / biosynthesis
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Muscle Strength
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / physiology
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Nitric Oxide / biosynthesis
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Oxygen Consumption
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Physical Conditioning, Human / physiology*
Substances
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Muscle Proteins
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Citrulline
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Nitric Oxide
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Arginine