Abstract
There have been controversies on the prophylactic effect of hydroxychloroquine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We describe a patient, 60-year old Korean woman, with coronavirus disease 2019 (COVID-19) who had been taking hydroxychloroquine for 6 months. Her serum and saliva concentrations of hydroxychloroquine were 280 μg/L and 4,890 μg/L, respectively. The present case raises concerns on hydroxychloroquine's role as a prophylactic agent for COVID-19.
Keywords:
COVID-19; Hydroxychloroquine; Prophylaxis; SARS-CoV-2.
© 2020 The Korean Academy of Medical Sciences.
MeSH terms
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Adenosine Monophosphate / analogs & derivatives
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Adenosine Monophosphate / therapeutic use
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Alanine / analogs & derivatives
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Alanine / therapeutic use
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Antiviral Agents / therapeutic use*
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Azithromycin / therapeutic use
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Betacoronavirus / drug effects*
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COVID-19
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Coronavirus Infections / drug therapy*
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Coronavirus Infections / prevention & control*
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Female
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Humans
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Hydroxychloroquine / therapeutic use*
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Middle Aged
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Pandemics / prevention & control*
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Pneumonia, Viral / drug therapy*
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Pneumonia, Viral / prevention & control*
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Primary Prevention / methods
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SARS-CoV-2
Substances
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Antiviral Agents
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remdesivir
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Adenosine Monophosphate
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Hydroxychloroquine
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Azithromycin
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Alanine