Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

Masaya Iwamuro; Toshi Murakami; Takehiro Tanaka; Shohei Oka; Seiji Kawano; Yoshiro Kawahara; Hiroyuki Okada

doi:10.1155/2020/6381670

Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

Case Rep Gastrointest Med. 2020 Jun 3:2020:6381670. doi: 10.1155/2020/6381670. eCollection 2020.

Authors

Masaya Iwamuro¹, Toshi Murakami², Takehiro Tanaka³, Shohei Oka¹, Seiji Kawano¹, Yoshiro Kawahara⁴, Hiroyuki Okada¹

Affiliations

¹ Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
² Satsuki Naika Clinic, Okayama 703-8258, Japan.
³ Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
⁴ Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital, Okayama 700-8558, Japan.

Abstract

A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient's request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.

Publication types

Case Reports