The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance. S100 proteins are also emerging as novel diagnostic markers for identifying and monitoring various diseases. Strategies aimed at targeting S100-mediated signaling pathways hold a great potential in developing novel therapeutics for multiple diseases. In this chapter, we aim to summarize the current knowledge about the role of S100 family proteins in health and disease with a major focus on their role in inflammatory conditions.
Keywords: Ca(2+) signaling; Cancer; Cardiomyocytes; Diabetes; EF-hand motif; Inflammasome; Inflammatory response; Inhibitors; Myocardial infarction; Obesity; Phagocytes; Psoriasis; S100 proteins; Sarcoplasmic reticulum; WBC.
© 2020 Elsevier Inc. All rights reserved.