Deceiving SARS-CoV-2 molecular-tropism clues - A combinational contemporary strategy

Med Hypotheses. 2020 Nov:144:109976. doi: 10.1016/j.mehy.2020.109976. Epub 2020 Jun 7.

Abstract

Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 frompreponetargets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificialsurfactantsystem as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2.

Keywords: ACE2 receptors; ARDS; COVID-19; Coronavirus; Molecular tropism; Pulmonary surfactant; SARS-CoV-2.

MeSH terms

  • Angiotensin-Converting Enzyme 2 / administration & dosage
  • Angiotensin-Converting Enzyme 2 / therapeutic use*
  • COVID-19 / complications
  • COVID-19 / prevention & control
  • COVID-19 / virology*
  • Drug Costs
  • Drug Delivery Systems
  • Erythrocytes*
  • Humans
  • Pulmonary Alveoli / drug effects
  • Pulmonary Alveoli / virology
  • Pulmonary Surfactants / administration & dosage
  • Pulmonary Surfactants / chemical synthesis
  • Pulmonary Surfactants / economics
  • Pulmonary Surfactants / therapeutic use*
  • Receptors, Virus / administration & dosage
  • Receptors, Virus / therapeutic use*
  • Respiratory Distress Syndrome / prevention & control
  • SARS-CoV-2 / physiology*
  • Viral Tropism*

Substances

  • Pulmonary Surfactants
  • Receptors, Virus
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2