pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients

Annemarie Broesder; Anne-Marijke M A C Kosta; Herman J Woerdenbag; Duong N Nguyen; Henderik W Frijlink; Wouter L J Hinrichs

doi:10.1016/j.drudis.2020.06.012

pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients

Drug Discov Today. 2020 Aug;25(8):1374-1388. doi: 10.1016/j.drudis.2020.06.012. Epub 2020 Jun 17.

Authors

Annemarie Broesder¹, Anne-Marijke M A C Kosta², Herman J Woerdenbag¹, Duong N Nguyen¹, Henderik W Frijlink¹, Wouter L J Hinrichs³

Affiliations

¹ University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
² University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells and Systems, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
³ University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address: w.l.j.hinrichs@rug.nl.

PMID: 32562842
DOI: 10.1016/j.drudis.2020.06.012

Abstract

Novel drugs and novel excipients in pH-dependent ileocolonic drug delivery systems have to be tested in animals. Which animal species are suitable and what in vivo methods are used to verify ileocolonic drug delivery?

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Colon / metabolism*
Drug Delivery Systems*
Drug Evaluation, Preclinical*
Excipients / administration & dosage*
Humans
Hydrogen-Ion Concentration
Ileum / metabolism*
Pharmaceutical Preparations / administration & dosage*

Substances

Excipients
Pharmaceutical Preparations