Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

Muneeb U Rehman; Adil Farooq; Rayeesa Ali; Sana Bashir; Nazirah Bashir; Samia Majeed; Syed Taifa; Sheikh Bilal Ahmad; Azher Arafah; Aga Syed Sameer; Rehan Khan; Wajhul Qamar; Saiema Rasool; Anas Ahmad

doi:10.2174/1389200221666200620204914

Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

Curr Drug Metab. 2020;21(6):436-465. doi: 10.2174/1389200221666200620204914.

Authors

Muneeb U Rehman¹, Adil Farooq², Rayeesa Ali³, Sana Bashir⁴, Nazirah Bashir⁴, Samia Majeed⁵, Syed Taifa⁶, Sheikh Bilal Ahmad⁴, Azher Arafah¹, Aga Syed Sameer⁷, Rehan Khan⁸, Wajhul Qamar⁹, Saiema Rasool¹⁰, Anas Ahmad⁸

Affiliations

¹ Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
² RAKCOPS, RAK Medical and Health Sciences University, Ras AL Khaimah, United Arab Emirates.
³ Division of Veterinary Pathology, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India.
⁴ Division of Veterinary Biochemistry, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India.
⁵ Division of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India.
⁶ Division of Animal Nutrition, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Shuhama, JandK, India.
⁷ Department of Basic Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Centre (KAIMRC), Jeddah, Saudi Arabia.
⁸ Department of Nano-therapeutics, Institute of Nanoscience and Technology (DST-INST), Mohali, Punjab, India.
⁹ Department of Pharmacology and Toxicology and Central Laboratory, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
¹⁰ Forest Biotech Lab, Department of Forest Mana pgement, Faculty of Forestry, University Putra Malaysia, Serdang, Selangor, Malaysia.

PMID: 32562521
DOI: 10.2174/1389200221666200620204914

Abstract

Glycyrrhiza glabra L. (Family: Fabaceae) is one of the important traditional medicinal plant used extensively in folk medicine. It is known for its ethnopharmacological value in curing a wide variety of ailments. Glycyrrhizin, an active compound of G. glabra, possesses anti-inflammatory activity due to which it is mostly used in traditional herbal medicine for the treatment and management of chronic diseases. The present review is focused extensively on the pharmacology, pharmacokinetics, toxicology, and potential effects of Glycyrrhizic Acid (GA). A thorough literature survey was conducted to identify various studies that reported on the GA on PubMed, Science Direct and Google Scholar.

Keywords: Glycyrrhiza glabra; anti-inflammatory; fabaceae; glycyrrhizin; liquorice; medicinal plant.

Publication types

Review

MeSH terms

Drug Evaluation, Preclinical*
Glycyrrhiza / chemistry*
Glycyrrhizic Acid / pharmacology*

Substances

Glycyrrhizic Acid