The crosstalk between cellular reprogramming and senescence in aging and regeneration

Aurélie Chiche; Cheng Chen; Han Li

doi:10.1016/j.exger.2020.111005

The crosstalk between cellular reprogramming and senescence in aging and regeneration

Exp Gerontol. 2020 Sep:138:111005. doi: 10.1016/j.exger.2020.111005. Epub 2020 Jun 17.

Authors

Aurélie Chiche¹, Cheng Chen¹, Han Li²

Affiliations

¹ Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France.
² Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France. Electronic address: han.li@pasteur.fr.

PMID: 32561400
DOI: 10.1016/j.exger.2020.111005

Abstract

Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation.

Keywords: Aging; Cellular plasticity; Cellular reprogramming; Cellular senescence; Regeneration; Rejuvenation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cellular Reprogramming*
Cellular Senescence*
Rejuvenation