The multiple functions of the co-chaperone stress inducible protein 1

Anna Carolina Carvalho da Fonseca; Diana Matias; Luiz Henrique Medeiros Geraldo; Felipe Saceanu Leser; Iohana Pagnoncelli; Celina Garcia; Rackele Ferreira do Amaral; Barbara Gomes da Rosa; Izabella Grimaldi; Eduardo Sabino de Camargo Magalhães; Valentín Cóppola-Segovia; Evellyn Mayla de Azevedo; Silvio Marques Zanata; Flavia Regina Souza Lima

doi:10.1016/j.cytogfr.2020.06.003

The multiple functions of the co-chaperone stress inducible protein 1

Cytokine Growth Factor Rev. 2021 Feb:57:73-84. doi: 10.1016/j.cytogfr.2020.06.003. Epub 2020 Jun 8.

Authors

Anna Carolina Carvalho da Fonseca¹, Diana Matias², Luiz Henrique Medeiros Geraldo³, Felipe Saceanu Leser⁴, Iohana Pagnoncelli⁴, Celina Garcia⁴, Rackele Ferreira do Amaral⁴, Barbara Gomes da Rosa⁴, Izabella Grimaldi⁴, Eduardo Sabino de Camargo Magalhães⁵, Valentín Cóppola-Segovia⁶, Evellyn Mayla de Azevedo⁶, Silvio Marques Zanata⁶, Flavia Regina Souza Lima⁷

Affiliations

¹ Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, 28625-650, Brazil.
² Molecular Bionics Laboratory, Department of Chemistry, University College London, London, WC1H 0AJ, United Kingdom.
³ Glial Cell Biology Laboratory, Biomedical Sciences Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-590, Brazil; Université de Paris, PARCC, INSERM, Paris, 75015, France.
⁴ Glial Cell Biology Laboratory, Biomedical Sciences Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-590, Brazil.
⁵ Glial Cell Biology Laboratory, Biomedical Sciences Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-590, Brazil; European Research Institute for the Biology of Aging, University of Groningen, Groningen, 9713 AV, Netherlands.
⁶ Departments of Basic Pathology and Cell Biology, Federal University of Paraná, Paraná, RJ, 81531-970, Brazil.
⁷ Glial Cell Biology Laboratory, Biomedical Sciences Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-590, Brazil. Electronic address: flaviareginasouzalima@gmail.com.

PMID: 32561134
DOI: 10.1016/j.cytogfr.2020.06.003

Abstract

Stress inducible protein 1 (STI1) is a co-chaperone acting with Hsp70 and Hsp90 for the correct client proteins' folding and therefore for the maintenance of cellular homeostasis. Besides being expressed in the cytosol, STI1 can also be found both in the cell membrane and the extracellular medium playing several relevant roles in the central nervous system (CNS) and tumor microenvironment. During CNS development, in association with cellular prion protein (PrP^c), STI1 regulates crucial events such as neuroprotection, neuritogenesis, astrocyte differentiation and survival. In cancer, STI1 is involved with tumor growth and invasion, is undoubtedly a pro-tumor factor, being considered as a biomarker and possibly therapeutic target for several malignancies. In this review, we discuss current knowledge and new findings on STI1 function as well as its role in tissue homeostasis, CNS and tumor progression.

Keywords: Cancer; Co-chaperone; Glia; Neuron; STI1; STIP1.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Heat-Shock Proteins
Humans
Molecular Chaperones*
Tumor Microenvironment

Substances

Heat-Shock Proteins
Molecular Chaperones