The importance of optimal ROIs delineation for FBPA-PET before BNCT

Yi-Wen Lo; Jia-Cheng Lee; Yong-Sin Hu; Chien-Ying Li; Yi-Lun Chen; Chi-Shuo Lin; Wen-Sheng Huang; Ko-Han Lin; Yi-Wei Chen

doi:10.1016/j.apradiso.2020.109219

The importance of optimal ROIs delineation for FBPA-PET before BNCT

Appl Radiat Isot. 2020 Sep:163:109219. doi: 10.1016/j.apradiso.2020.109219. Epub 2020 May 13.

Authors

Yi-Wen Lo¹, Jia-Cheng Lee², Yong-Sin Hu³, Chien-Ying Li¹, Yi-Lun Chen¹, Chi-Shuo Lin², Wen-Sheng Huang¹, Ko-Han Lin⁴, Yi-Wei Chen⁵

Affiliations

¹ Integrated PET/MR Imaging Centre, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
² Division of Radiotherapy, Department of Oncology Medicine, Taipei Veterans General Hospital, Taiwan.
³ Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
⁴ Integrated PET/MR Imaging Centre, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: khlin3@vghpe.gov.tw.
⁵ Division of Radiotherapy, Department of Oncology Medicine, Taipei Veterans General Hospital, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: chenyw@vghtpe.gov.tw.

PMID: 32561058
DOI: 10.1016/j.apradiso.2020.109219

Abstract

One of the eligible criteria for patients to receive boron neutron capture therapy (BNCT) is based on the tumour-to-normal ratio (T/N) measured by FBPA-PET. However, there is no standard protocol for normal region-of-interested delineation. With comparison of contralateral cerebrum, our study revealed the consistency (p < 0.05) and high feasibility using the cerebellum as an alternative normal tissue baseline because of its homogeneous uptake. Following RECIST version 1.1, the standard-operating-procedure (SOP) for the BNCT fulfilled the expected tumour response and tumour shrinkage rate (p < 0.05). Our modified procedure can provide more precise information for BNCT within a reasonable time.

Keywords: BNCT; Brain stem; Cerebellum; FBPA-PET/CT; ROI; Tumour response.

MeSH terms

Boron Compounds / administration & dosage*
Boron Neutron Capture Therapy / methods*
Brain Neoplasms / radiotherapy*
Feasibility Studies
Humans
Phenylalanine / administration & dosage
Phenylalanine / analogs & derivatives*
Positron-Emission Tomography / methods*

Substances

Boron Compounds
4-borono-2-fluorophenylalanine
Phenylalanine