Biodistribution studies of boronophenylalanine in different types of skin melanoma

Appl Radiat Isot. 2020 Sep:163:109215. doi: 10.1016/j.apradiso.2020.109215. Epub 2020 May 11.

Abstract

A study of the 10B-enriched Boronophenylalanine-fructose complex(10BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. 10B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios. T/B ratio for three melanoma patients was in the range 1.48-3.82(average 2.56 ± 0.69). S/B ratio was in the range 0.81-1.99(average 1.29 ± 0.35). Results showed that T/B ratio of nodular metastasis melanoma was higher than superficial spreading melanoma. 10B concentration in skin was higher than blood, which was helpful to avoid over-dose in normal skin.

Keywords: BNCT; BPA; Boron concentration; Melanoma.

MeSH terms

  • Aged
  • Boron Compounds / metabolism*
  • Fructose / analogs & derivatives*
  • Fructose / metabolism
  • Humans
  • Male
  • Melanoma / metabolism*
  • Melanoma / pathology
  • Middle Aged
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Tissue Distribution

Substances

  • 4-boronophenylalanine-fructose
  • Boron Compounds
  • Fructose