The Roles of Alternative Splicing in Tumor-immune Cell Interactions

Yue Wang; Honglei Zhang; Baowei Jiao; Jianyun Nie; Xiyin Li; Wenhuan Wang; Hairui Wang

doi:10.2174/1568009620666200619123725

The Roles of Alternative Splicing in Tumor-immune Cell Interactions

Curr Cancer Drug Targets. 2020;20(10):729-740. doi: 10.2174/1568009620666200619123725.

Authors

Yue Wang^{1

2}, Honglei Zhang^{2

3}, Baowei Jiao^{2

4

5}, Jianyun Nie^{1

6}, Xiyin Li^{1

2}, Wenhuan Wang¹, Hairui Wang^{1

2}

Affiliations

¹ Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
² State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
³ Yunnan University of Chinese Medicine, Kunming 650500, China
⁴ KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
⁵ Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China
⁶ Department of Breast Cancer, Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China

Abstract

Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5, MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.

Keywords: Alternative splicing; Tumor specific-antigens (TSAs); immune system; immunotherapy; neoantigens; tumor cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alternative Splicing*
Animals
Antigens, Neoplasm / genetics
Antigens, Neoplasm / immunology*
Cell Communication*
Humans
Lymphocytes / immunology*
Neoplasms / genetics
Neoplasms / immunology*
Neoplasms / pathology
Tumor Microenvironment*

Substances

Antigens, Neoplasm

Grants and funding

This work was supported by the National Natural Science Foundation of China [grant No.81960479, No.81760480 and No.81360392] (to Jianyun Nie); [grant No. 31801249] (to Honglei Zhang).